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Patients should be monitored for serious adverse effects including pancreatitis (severe persistent abdominal pain), gallbladder disease (right upper quadrant pain, fever, jaundice), acute kidney injury (especially with dehydration from gastrointestinal side effects), diabetic retinopathy complications (sudden visual changes), and hypersensitivity reactions

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NNMT inhibition addresses this metabolic impairment by enhancing cellular energy metabolism and improving insulin signaling pathways